Molecular Inclusion Complex of Curcumin–β-Cyclodextrin Nanoparticle to Enhance Curcumin Skin Permeability from Hydrophilic Matrix Gel
نویسندگان
چکیده
منابع مشابه
Β-cyclodextrin Inclusion Complex of Curcumin
Formation of inclusion complex of curcumin with β-cyclodextrin ( β-CD) has been characterized by absorption and fluorescence spectroscopy. From temperature-dependent fluorescence measurements, the thermodynamic parameters ∆H and ∆S, for the complexation were estimated. Kinetics of binding was studied by stopped flow technique, from which the binding constants for inclusion complex was estimated...
متن کاملCyclodextrin Inclusion Complex to Enhance Solubility of Poorly Water Soluble Drugs: a Review
Low solubility compounds show dissolution rate limited absorption and hence poor absorption, distribution and target organ delivery. Improvement of aqueous solubility in such a case is valuable goal to improve therapeutic efficacy. Complexation with CDs by different methods like physical mixing, melting, kneding, spray drying, freeze drying, co-evaporation has been reported to enhance the solub...
متن کاملPhysicochemical Characterizations, Dissolution Behavior and Release Kinetics of Curcumin and Β-cyclodextrin Molecular Inclusion Complexes
This paper presents physicochemical characterization, dissolution behavior and release kinetics of curcumin and its molecular inclusion complexes with β-cyclodextrin. Solid inclusion complexes of curcumin with β-cyclodextrin in 1:2 molar ratios were prepared by grinding, kneading and freeze drying methods. Complexes were characterized by differential scanning calorimetry, infra red spectroscopy...
متن کاملCore-shell nanofibers of curcumin/cyclodextrin inclusion complex and polylactic acid: Enhanced water solubility and slow release of curcumin.
Core-shell nanofibers were designed via electrospinning using inclusion complex (IC) of model hydrophobic drug (curcumin, CUR) with cyclodextrin (CD) in the core and polymer (polylactic acid, PLA) in the shell (cCUR/HPβCD-IC-sPLA-NF). CD-IC of CUR and HPβCD was formed at 1:2 molar ratio. The successful formation of core-shell nanofibers was revealed by TEM and CLSM images. cCUR/HPβCD-IC-sPLA-NF...
متن کاملPhysicochemical characterizations and dissolution behavior of curcumin and α-cyclodextrin molecular inclusion complexes
The aim of present work was to enhance the aqueous solubility and dissolution rate of the curcumin, a water insoluble yellow colored phenolic pigment with good anti-inflammatory property obtained from dried rhizomes of plant Cucrcuma longa. This paper presents physicochemical evaluations of curcumin and its molecular inclusion complexes with α-cyclodextrin. Phase solubility studies revealed lin...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2013
ISSN: 1530-9932
DOI: 10.1208/s12249-013-0023-5